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Google combs more Web pages, faster, than any other search engine. But perhaps just as impressive Is that despite the dot-conn melt-down, the company has never veered from its mission. Competitors have tried to reposition themselves as all-purpose "portals,' only to slip from the radar screen. That thrills Google cofounder Larry Page, a feisty roller hockey player. Google has continued to expand the kinds of data it searches, recently adding Usenet news groups and retall catalogues. And it keeps expanding its tool set: for instance, Google now serves its results to ceil phones. Copresidents Page and Sergey Brin (p. 69) have worked as equal teammates since they first revised their unique search software and went live in 1998. They are both competitive but know how productive they are working together. Their responsibilities often overlap, and they still share an office. For thein, Google is about solving intellectual problems. Lndeed, they recently recruited Novell and Sun veteran Eric Schmidt as CEO to manage their 300-plus employees, so they can continue to focus on technology."0ur goal is to keep innovating, "Page says.
PAGE
LARRY
AGE 29
INTERNET AND WEB
GOOGLE

If scientists understood how the body's ! Proteins folded. They could better battle diseases like Aizheimer's. But analyzing a pro- tein's trillions of possible folding steps is daunting, even for a supercomputer. In 1999 Vijay Pande, a professor of chemistry and structural biology at Stanford University, wrote algorithms that enable thousands of isolated computers to calculate tiny portions of a folding sequence and combine their solu- tions. The pragmatic Pande then sought advice from distributed-computing entrepreneur Adam Beberg (a formerTR100 onoree) on how to integrate his code into a screen saver that PC users could download. Dubbed Folding@home, the software makes calculations any time the PC's screen saver is running and reports the results to Pande's computer. Since the project's October 2000 debut, some 75,000 volunteers worldwide have helped simulate, for the first time, the complete folding behavior of five important proteins. Born in Trinidad to Indian parents, Pande is now using distributed computing to map the final folded structures of the proteins.0n any given day, 35,000 PCs are providing the computing power.
PANDE
VIJAY
AGE 31
BIOTECHNOLOGY
STANFORD UNIVERSITY

Think of Suzie Hwang Pun as a traffic cop for genes. The chemical engineer uses polymers to carry injected genes through the bloodstream. With a system of molecular tags, she can direct a gene—say, one that blocks cancer progression—to just the right spot—like the nuclei of cells in a tumor. It's a trick that could solve ahuge problem in gene therapy research: a new gene does no good if it doesn't make it to the right place. White viruses are the typical delivery vehicles in gene therapy, they're hard to manufacture and can be intercepted by the immune system. Pun's materials avoid those problems and open the possibility of delivering drugs, as well as genes, with exquisite precision." This is the tip of the iceberg," says Caltech chemical engineer Mark Davis. He was so excited by Pun's accomplishments as a graduate student in his lab that he founded Insert Therapeutics in Pasadena, CA, primarily to commercialize her work. The clear-spoken Pun jumped at the chance to be a senior scientist and employee number one. If all goes well, her technology could enter human trials within a few years.
PUN
SUZIE HWANG
AGE 27
MEDICINE
INSERT THERAPEUTICS

Source From: TECHNOLOGY REVIEW June 2002
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